This version of BRAVO variant browser shows chromosome locations (on GRCh38 human genome assembly), alleles, functional annotations, and allele frequencies for 705 million variants observed in 132,345 deeply sequenced (>38X) genomes from the TOPMed (Trans-Omics for Precision Medicine) data freeze 8.
The TOPMed program is sponsored by the National Institutes of Health (NIH) National Heart, Lung and Blood Institute (NHLBI) and aims to improve our understanding of heart, lung, blood and sleep disorders by adding deep whole-genome sequencing data to existing high-priority studies of these conditions.
The variant level summary information is shared through BRAVO by the following TOPMed studies (visit here for a complete list of all TOPMed studies) and is available for users that agree to the terms:
| Study | PI(s) |
|---|---|
| Atrial Fibrillation Biobank Ludwig Maximilian University Study | Mortiz Sinner, Stefan Kaab |
| Genetics of Cardiometabolic Health in the Amish | Braxton D. Mitchell |
| Atherosclerosis Risk in Communities Study VTE cohort | Eric Boerwinkle |
| Molecular Mechanisms of Inherited Cardiomyopathies and Arrhythmias in the Australian Familial AF Study | Diane Fatkin |
| New Approaches for Empowering Studies of Asthma in Populations of African Descent - Barbados Asthma Genetics Study | Kathleen Barnes |
| Mount Sinai BioMe Biobank | Ruth J.F. Loos, Eimear Kenny |
| The Vanderbilt University BioVU Atrial Fibrillation Genetics Study | M. Benjamin Shoemaker, Dan Roden |
| Childhood Asthma Management Program | Scott Weiss |
| Coronary Artery Risk Development in Young Adults | Myriam Fornage, Donald Lloyd-Jones, Lifang Hou |
| Cleveland Clinic Atrial Fibrillation Study | Mina Chung, John Barnard |
| Cleveland Family Study - WGS Collaboration | Susan Redline |
| Children's Health Study: Integrative Genetic Approaches to Gene-Air Pollution Interactions in Asthma | Frank Gilliland |
| Children's Health Study: Integrative Genomics and Environmental Research of Asthma | Frank Gilliland |
| Children's Health Study: Effects of Air Pollution on the Development of Obesity in Children | Frank Gilliland |
| Genetics Sub-Study of Chicago Initiative to Raise Asthma Health Equity | Rajesh Kumar |
| Cardiovascular Health Study | Bruce Psaty, Russell Tracy |
| Genetic Epidemiology of COPD Study | Edwin Silverman |
| The Genetic Epidemiology of Asthma in Costa Rica - Asthma in Costa Rica cohort | Scott Weiss |
| Determining the association of chromosomal variants with non-PV triggers and ablation-outcome in DECAF | Sanghamitra Mohanty, Andrea Natale |
| Diabetes Heart Study | Nicholette Palmer, Donald W. Bowden |
| Evaluation of COPD Longitudinally to Identify Predictive Surrogate End-points | Edwin Silverman |
| Boston Early-Onset COPD Study | Edwin Silverman |
| Framingham Heart Study | Vasan S. Ramachandran, Dan Levy, L. Adrienne Cupples |
| ATGC Gene-Environment, Admixture and Latino Asthmatics Study I Asthma | Esteban Burchard |
| Gene-Environment, Admixture and Latino Asthmatics Study | Esteban Burchard |
| Genetics of Complex Pediatric Disorders - Asthma | Hakon Hakonarson |
| Genetic Studies of Atherosclerosis Risk | Rasika Mathias |
| Genetic Epidemiology Network of Arteriopathy | Sharon Kardia, Jennifer Smith |
| Genetic Epidemiology Network of Salt Sensitivity | Jiang He |
| Groningen Genetics of Atrial Fibrillation Study | Michiel Rienstra |
| Genetics of Lipid Lowering Drugs and Diet Network | Donna K Arnett |
| Hispanic Community Health Study - Study of Latinos | Robert Kaplan, Kari North |
| Heart and Vascular Health Study | Susan Heckbert |
| Hypertension Genetic Epidemiology Network | Donna K Arnett |
| Whole Genome Sequencing in Familial and Sporadic Idiopathic Pulmonary Fibrosis | David Schwartz, Tasha Fingerlin |
| Jackson Heart Study | Adolfo Correa, James Wilson |
| The Johns Hopkins University School of Medicine Atrial Fibrillation Genetics Study | Saman Nazarian |
| Lung Tissue Research Consortium | Edwin Silverman |
| Mayo Clinic Venous Thromboembolism Study | Mariza de Andrade |
| Multi-Ethnic Study of Atherosclerosis | Jerome Rotter, Stephen Rich |
| Massachusetts General Hospital Atrial Fibrillation Study | Patrick Ellinor |
| My Life, Our Future: Genotyping for Progress in Hemophilia | Barbara Konkle, Jill Johnsen |
| Outcome Modifying Genes in Sickle Cell Disease | Allison Ashley-Koch, Marilyn Telen |
| Partners Healthcare Biorepository | Steven Lubitz |
| Pediatric Cardiac Genomics Consortium's Congenital Heart Disease Biobank | Bruce Gelb, Christine Seidman |
| The Pharmacogenomics of Hydroxyurea in Sickle Cell Disease | Stephanie L. Sherman |
| Early-onset Atrial Fibrillation in the Penn Medicine BioBank Cohort | Daniel Rader, Scott Damrauer |
| Pulmonary Hypertension and the Hypoxic Response in Sickle Cell Disease | Sergei Nekhai |
| Recipient Epidemiology and Donor Evaluation Study-III | Brian Custer, Shannon Kelly |
| Whole Genome Sequencing to Identify Causal Genetic Variants Influencing CVD Risk - San Antonio Family Studies | John Blangero, Joanne Curran |
| Study of African Americans, Asthma, Genes and Environment | Esteban Burchard |
| Study of Asthma Phenotypes & Pharmacogenomic Interactions by Race-Ethnicity | L. Keoki Williams |
| Genetics of Sarcoidosis in African Americans | Courtney Montgomery |
| Severe Asthma Research Program | Deborah A. Meyers |
| Taiwan Study of Hypertension using Rare Variants | D.C. Rao, Yii-Der Ida Chen |
| Vanderbilt Atrial Fibrillation Ablation Registry | M. Benjamin Shoemaker |
| Vanderbilt Genetic Basis of Atrial Fibrillation | Dawood Darbar |
| Women's Health Initiative | Charles Kooperberg, Alex Reiner |
The sequencing analysis pipeline consists of two major processes:
If you have a question about BRAVO, contact bravo-group@umich.edu