This version of BRAVO variant browser shows chromosome locations (on GRCh38 human genome assembly), alleles, functional annotations, and allele frequencies for 705 million variants observed in 132,345 deeply sequenced (>38X) genomes from the TOPMed (Trans-Omics for Precision Medicine) data freeze 8.

The TOPMed program is sponsored by the National Institutes of Health (NIH) National Heart, Lung and Blood Institute (NHLBI) and aims to improve our understanding of heart, lung, blood and sleep disorders by adding deep whole-genome sequencing data to existing high-priority studies of these conditions.

The variant level summary information is shared through BRAVO by the following TOPMed studies (visit here for a complete list of all TOPMed studies) and is available for users that agree to the terms:

Study PI(s)
Atrial Fibrillation Biobank Ludwig Maximilian University Study Mortiz Sinner, Stefan Kaab
Genetics of Cardiometabolic Health in the Amish Braxton D. Mitchell
Atherosclerosis Risk in Communities Study VTE cohort Eric Boerwinkle
Molecular Mechanisms of Inherited Cardiomyopathies and Arrhythmias in the Australian Familial AF Study Diane Fatkin
New Approaches for Empowering Studies of Asthma in Populations of African Descent - Barbados Asthma Genetics Study Kathleen Barnes
Mount Sinai BioMe Biobank Ruth J.F. Loos, Eimear Kenny
The Vanderbilt University BioVU Atrial Fibrillation Genetics Study M. Benjamin Shoemaker, Dan Roden
Childhood Asthma Management Program Scott Weiss
Coronary Artery Risk Development in Young Adults Myriam Fornage, Donald Lloyd-Jones, Lifang Hou
Cleveland Clinic Atrial Fibrillation Study Mina Chung, John Barnard
Cleveland Family Study - WGS Collaboration Susan Redline
Children's Health Study: Integrative Genetic Approaches to Gene-Air Pollution Interactions in Asthma Frank Gilliland
Children's Health Study: Integrative Genomics and Environmental Research of Asthma Frank Gilliland
Children's Health Study: Effects of Air Pollution on the Development of Obesity in Children Frank Gilliland
Genetics Sub-Study of Chicago Initiative to Raise Asthma Health Equity Rajesh Kumar
Cardiovascular Health Study Bruce Psaty, Russell Tracy
Genetic Epidemiology of COPD Study Edwin Silverman
The Genetic Epidemiology of Asthma in Costa Rica - Asthma in Costa Rica cohort Scott Weiss
Determining the association of chromosomal variants with non-PV triggers and ablation-outcome in DECAF Sanghamitra Mohanty, Andrea Natale
Diabetes Heart Study Nicholette Palmer, Donald W. Bowden
Evaluation of COPD Longitudinally to Identify Predictive Surrogate End-points Edwin Silverman
Boston Early-Onset COPD Study Edwin Silverman
Framingham Heart Study Vasan S. Ramachandran, Dan Levy, L. Adrienne Cupples
ATGC Gene-Environment, Admixture and Latino Asthmatics Study I Asthma Esteban Burchard
Gene-Environment, Admixture and Latino Asthmatics Study Esteban Burchard
Genetics of Complex Pediatric Disorders - Asthma Hakon Hakonarson
Genetic Studies of Atherosclerosis Risk Rasika Mathias
Genetic Epidemiology Network of Arteriopathy Sharon Kardia, Jennifer Smith
Genetic Epidemiology Network of Salt Sensitivity Jiang He
Groningen Genetics of Atrial Fibrillation Study Michiel Rienstra
Genetics of Lipid Lowering Drugs and Diet Network Donna K Arnett
Hispanic Community Health Study - Study of Latinos Robert Kaplan, Kari North
Heart and Vascular Health Study Susan Heckbert
Hypertension Genetic Epidemiology Network Donna K Arnett
Whole Genome Sequencing in Familial and Sporadic Idiopathic Pulmonary Fibrosis David Schwartz, Tasha Fingerlin
Jackson Heart Study Adolfo Correa, James Wilson
The Johns Hopkins University School of Medicine Atrial Fibrillation Genetics Study Saman Nazarian
Lung Tissue Research Consortium Edwin Silverman
Mayo Clinic Venous Thromboembolism Study Mariza de Andrade
Multi-Ethnic Study of Atherosclerosis Jerome Rotter, Stephen Rich
Massachusetts General Hospital Atrial Fibrillation Study Patrick Ellinor
My Life, Our Future: Genotyping for Progress in Hemophilia Barbara Konkle, Jill Johnsen
Outcome Modifying Genes in Sickle Cell Disease Allison Ashley-Koch, Marilyn Telen
Partners Healthcare Biorepository Steven Lubitz
Pediatric Cardiac Genomics Consortium's Congenital Heart Disease Biobank Bruce Gelb, Christine Seidman
The Pharmacogenomics of Hydroxyurea in Sickle Cell Disease Stephanie L. Sherman
Early-onset Atrial Fibrillation in the Penn Medicine BioBank Cohort Daniel Rader, Scott Damrauer
Pulmonary Hypertension and the Hypoxic Response in Sickle Cell Disease Sergei Nekhai
Recipient Epidemiology and Donor Evaluation Study-III Brian Custer, Shannon Kelly
Whole Genome Sequencing to Identify Causal Genetic Variants Influencing CVD Risk - San Antonio Family Studies John Blangero, Joanne Curran
Study of African Americans, Asthma, Genes and Environment Esteban Burchard
Study of Asthma Phenotypes & Pharmacogenomic Interactions by Race-Ethnicity L. Keoki Williams
Genetics of Sarcoidosis in African Americans Courtney Montgomery
Severe Asthma Research Program Deborah A. Meyers
Taiwan Study of Hypertension using Rare Variants D.C. Rao, Yii-Der Ida Chen
Vanderbilt Atrial Fibrillation Ablation Registry M. Benjamin Shoemaker
Vanderbilt Genetic Basis of Atrial Fibrillation Dawood Darbar
Women's Health Initiative Charles Kooperberg, Alex Reiner

The sequencing analysis pipeline consists of two major processes:

  • Harmonization of read alignments in the sequence data provided by the sequencing centers;
  • Joint variant discovery and genotype calling across studies using the GotCloud pipeline.
More detailed description of data processing methods for each data freeze is available on the TOPMed page.

If you have a question about BRAVO, contact bravo-group@umich.edu